An RNA guide targets the Cas9 nuclease through complementary binding. The variable guide length allows for relatively easy design with high specificity to the target site. Image credit: Genome Research Limited
![](https://bioscope.faculty.ucdavis.edu/wp-content/uploads/sites/490/2019/03/CRISPR-Cas9-Credit-Genome-Research-Limited-from-yourgenome.org--900x484.png)
An RNA guide targets the Cas9 nuclease through complementary binding. The variable guide length allows for relatively easy design with high specificity to the target site. Image credit: Genome Research Limited
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